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Taken together, these data show that our primary screen can identify mutants with normal short-term memory, but deficient remote memory.
Despite the decreased kidney size, renal function did not appear to be altered in the double mutants, with normal levels of serum and urine markers testing kidney function (data not shown).
These mutant classes include eggshell-defective mutants, sterile or small brood-producing mutants, mutants with delayed progression through S phase, and mutants with normal early embryonic cell divisions but highly penetrant lethality presumably due to defects later in embryogenesis.
In contrast to mutants with normal RGC projection (bel fwd), achiasmatic larvae (bel rev) display two characteristic oculomotor instabilities that can be completely attributed to the RGC misrouting due to a sign-reversed afference signal: reversed OKR and involuntary oscillatory eye movements (congenital nystagmus, CN) [4], [5].
Previous results [8] detect no more than two parameters from the hmg1 and hmg2 mutants with normal distributions on one side at P<0.0001, suggesting that our high-content image-profiling method can detect mutants of genes with major cellular roles even if the mutant show a weak phenotype.
Three mutants with normal oocyst maturation showed a marked reduction of salivary gland infections.
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Peng [ 5] selected a three-pistil (TP) mutant with normal spike morphology that produced three pistils per floret.
It can indeed happen that a mutant with normal copolymerization capacity in vitro, behaves abnormally in the cellular context (e.g. α-actin mutant H40Y in (40)).
In each case, the conditionally null mutants with a normal external phenotype had normal hearts.
The carrier frequencies of sine and pulse song also varied in an allele-specific manner: fruA mutants had higher-frequency sine song and lower-frequency pulse song, fruB mutants sang with normal carrier frequencies, and for fruC the carrier frequency of pulse song was highly variable but not significantly different than that of fruF /+ control males.
To investigate this, we monitored phosphorylation of the Nodal intracellular signal transducer Smad2 in oep mutants with a normal or down regulated expression of rasl11b.
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