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The log-fold change distributions of known miRNA targets were also very similar between mutants with large transcriptome changes and mutants with small transcriptome changes (Figure S2).
Our results showed that for chrysotile-induced λ mutants the ratios of mutants with large deletions were similar to those induced by H2O2 at equitoxic doses.
The strategy z* = 0 may be locally stable without being globally stable: < 0 does not exclude that mutants with large effects could invade (for examples, see [ 32, 33]).
Compared with control hippocampi, we observed highly disorganized projection patterns of mossy fibres in Bcl11b mutants, with large amounts of axons travelling aberrantly along the infrapyramidal tract and scattered over the entire pyramidal cell band of the CA3 region.
Interestingly, however, mutants with "large" birth size still did not display a significant overall shift in their DNA content (see Figure 5, P > 0.20, Table S1, and File S1).
The rate is determined primarily by the distribution among mutants of small effect; mutants with large deleterious effects are extremely unlikely to fix, and there can be few reversals of such fixations if they rarely happen in the first place.
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C-strain mutants with larger deletions were highly debilitated and incapable of sustained growth in vitro.
Yet in case of local feedback mutants with larger bites failed to establish.
Comparison of transcripts with increased or decreased expression for each of the mutants showed 84 increased and 159 decreased genes were shared between two or three mutants, with larger numbers of genes being uniquely differentially expressed in individual mutants (Fig. 3A).
However, the subset of mutants examined in this study may not be representative of the population, as they were predominately composed of visible phenotype mutants and included 10 reverse screen mutant families with large duplications.
And while there is certainly a very popular place for men in capes, or dressed as animals, or part men/part animal hero mutants with very large guns, there is also a place, perhaps smaller, for something a little more challenging.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com