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Mutants with abnormal patterns of locomotion, also known as uncoordinated (Unc) mutants, have facilitated the genetic dissection of many important aspects of nervous system function and development in the nematode Caenorhabditis elegans.
To dissect genetically a xenobiotics response pathway (xrep) from a target of xenobiotics to the final destination of phase II enzyme expression, we isolated xrep gene mutants with abnormal GST expression or response to acrylamide.
We found that mutants defective in mechanosensation (mec-4, mec-10) or mutants with abnormal waveforms (unc-29) did not perform this enhanced locomotion and moved much more slowly than wild-type worms in the microstructure.
A screen designed to isolate medaka mutants with abnormal livers identified the namako (nmk) mutant (Miyake et al., 2008).
We therefore decided to systematically screen mutants with abnormal dendrite morphogenesis for defects in synapse formation and maintenance.
Analysis of mutants with abnormal flowering time has allowed the identification of genes controlling floral transition [ 8].
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We conclude that the mutant with abnormal muscle responded to microgravity by increasing the total amount of muscle protein in order to compensate for the loss of muscle function.
On a spontaneous sweet orange bud mutant with abnormal lycopene accumulation in fruits and its wild type, comparative transcripts profiling was performed using Massively Parallel Signature Sequencing (MPSS).
In 2007, Keays et al. [ 97] reported the identification of a mouse mutant with abnormal laminar architecture of the hippocampus and cerebral cortex resulting from impaired radial neuronal migration.
Moreover, the threshold of the PSII protein phosphorylation between the stn8 and stn7stn8 protein kinase mutants with the abnormal grana size of the tylakoids and the wild type and stn7 Arabidopsis plants with the normal membrane organization [7] remains to be determined.
Deletion mutants with an abnormal morphology, not present in the natural yeast strains, may be missing from the natural population due to their slow growth.
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mutants with irregular
mutants with transcriptional
mutants with large
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mutants with critical
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