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To identify yeast mutants with a point mutation, detection of the specific mutant alleles is necessary.
You do find things like axes but, while they will dispatch mutants with a single blow, they disintegrate after a single use.
BChE mutants with a higher catalytic activity against -cocaine are highly desired for use as an exogenous enzyme in humans.
Figure 6b shows the results of introducing type 2 cell mutants with a higher B production efficiency in our metapopulation model.
The computational results provide valuable insights into future design of BChE mutants with a higher catalytic activity for -cocaine.
In Fig. 6d, e, we investigate the appearance of paradox 2 by considering invasions of type 2 cell mutants with a higher efficiency of making the A metabolite.
This was accomplished by generating mutants with a stabilized active form and destabilized polymerized form, or the converse.
This segment is now being targeted by random mutagenesis to select mutants with a preference for natural estradiol compared to the branched hapten.
The simulation result is, however, in agreement with the recent NMR detection of folded monomers of HIV-1 PR mutants with a destabilized interface.
This indicates that some of the mechanisms are shared among the strains of different genotypes, as was demonstrated e.g. for strains susceptible only to phage mutants with a truncated endolysin gene26.
However 3 mutants with a low MER were constructed with TAF23 using the same concentration.
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