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These mutants will arise after a few days of an infection in a host in which the virus replicates efficiently (Fig. 2A) and would be delayed if replication is impaired (fig. S5).
Over time, random mutants will arise in this population.
Similar(58)
Since the generation time of individual organisms is likely to be much shorter than that of groups, the probability that a selfish mutant will arise and spread is very high, according to this line of argument.
If the viral load equilibrates much faster after the emergence of a new mutant than the next mutant arises we can assume that new mutants will approximately arise at a rate proportional to the equilibrium viral load v(n R 5, n X 4).
For large populations, the probability that deleterious intermediates will fix declines drastically, and successful double mutants will instead arise on the unfixed single-mutant background in a process known as stochastic tunneling [ 16].
Note that this effect will arise in any model of mutation-selection balance that correctly takes into account the coupling of different mutants at high mutation rate.
Frustrations will arise.
But new issues will arise.
Sooner or later a successor will arise.
The dispute will arise again in 2001.
This is where conflict will arise.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com