By E14.5, Q was 0.51±0.01 in control animals versus 0.44±0.01 in Sall1 mutants, which represents a 13.7% decrease compared with controls (Fig. 6C; n=3, P<0.05).
The binding site of the core of the inhibitors, catechol bisphosphate (1), on STAT5b was characterized by point mutants, which represents the first point mutant validation of a small-molecule inhibitor of a STAT SH2 domain.
Here, we introduced the dgf zebrafish mutant, which represents a valuable model for investigating Enpp1 function and ectopic mineralization, and extend, through the present analysis, our understanding of Enpp1 function in vivo.
In a previous work [ 19] we had constructed the A441I mutant, which represents the putative original ALDH10 isoenzyme with only AMADH activity, i.e., devoid of significant BADH activity, and the A441C mutant, which, together with the wild-type SoBADH, represents those isoenzymes that in addition to the AMADH activity also have BADH activity.
Of the sequenced mutants, 33 contained a single point mutation, which represented 32 unique mutations.
The expected mutant phenotypes, which represent phenotypes of double mutants in the absence of genetic interactions, are given by a matrix H.
The International Rice Functional Genomics Consortium announced the public availability of more than 200,000 rice mutant lines, which represent mutations in about half of the known functional genes mapped for rice to date (Krishnan et al. 2009).
Finally, to better define the molecular anatomy of diabetic nephropathy, we analyzed the altered gene expression patterns of glomerular endothelial cells in db/db mutant mice, which represent a useful model of this disease.
In p53 mutant advanced serous ovarian cancers, which represent the vast majority of patients, Δ133p53 expression levels discriminate between two groups of patients with substantially different clinical outcome.
We examined renal endothelial cells from the embryo and from the adult glomerulus, cortex and medulla compartments, as well as the glomerular endothelial cells of the db/db mutant mouse, which represents a model for human diabetic nephropathy.
