Sentence examples for mutants which affect from inspiring English sources
We propose that such mutants mark alternatively spliced exons whereas mutants which affect all three phenotypes (dpolv) are located in constitutive exons.
A chloroplast copper transporter was identified by a complementation group of NPQ-deficient mutants, which affect electron transport by restricting the supply of copper for holoplastocyanin assembly in the thylakoid lumen [8].
In fact, it has been proposed that the effects observed in mouse Dax1 mutants, which affect normal granulosa cell organization around oocytes in females, could be functionally related to the defects in Sertoli cell support of germ cells observed in males [70].
Focusing on the Batumi and Roo transposons, we observed that primary piRNAs were preferentially lost in vret mutants, almost exclusively leaving 10 nt offset 'ping-pong' pairs in vret mutant ovaries (Fig. 6F,G); this is similar to observations in armi and piwi mutants, and in contrast to aub mutants, which affect 'ping-pong' amplification (Fig. 6F) (Malone et al., 2009; Olivieri et al., 2010).
First, the let-23(n1045) hypomorphic mutant, which affects an EGF receptor, was crossed with ndk-1 ok314 ndk-1 ok314
First, we observed that the FLAG-tagged K498A substitution mutant, which affects an ATP binding residue and abolishes the ATPase activity of UPF1 (Cheng et al., 2007) and is hyperphosphorylated displayed similar binding to T7-tagged DHX34 as the wild-type FLAG-UPF1 protein.
By transferring the mutant mtDNA in transmitochondrial cytoplasmic hybrid (cybrid) cells we established the pathogenic role of this mutation, which affects CI function in homoplasmic mutant cybrids.
These mutant proteins, which affect the chaperone-dependent assembly of tubulin heterodimers in different ways, disrupt neurogenic division and/or migration in vivo.
Thus mutants which impact the movement of DIIIS4 may affect both channel activation and fast inactivation.
In tests for interactions with other proteins, we find that mutants of alpha Tub67C, which affect an oocyte- and early embryo-specific alpha-tubulin, enhance meiotic nondisjunction and zygotic loss of ncdD, a partial loss-of-function mutant of ncd.
Importantly, the levels of UPF1 phosphorylation were rescued upon the expression of an shRNA-resistant wild-type DHX34 construct, but not by the ATPase-deficient DHX34 mutants (K191S or D279A), which affect ATP binding or ATP hydrolysis, respectively.
