It should be noted that the frequency of spindle misorientation in apc2d40/apc2N175K mutants was somewhat lower than previously reported (∼10%), likely due to a change in fixation procedure (see Materials and Methods).
The discovery of absence seizures in Scn8a mutants is somewhat surprising, because these mice have been studied for many years.
Indeed, the observation that the phenotype of disease mutants is somewhat altered by adding the Q67L mutation (Fig. 6A C) provides indirect evidence that a modest amount of GTP hydrolysis does occur in disease mutants in vivo.
Obtained results showed that Δ377 mutant was somewhat more virulent than the wild type (Fig. 7).
The behavior of the D116N mutant is somewhat surprising.
Nevertheless, the unusual mode of Be neutralization by the QacR(E58Q) mutant is somewhat similar to what has been observed in the QacR−Pt complex (27).
The behavior of the TRIP13E253Q/W221A mutant is somewhat mysterious, and a full explanation will likely require a more comprehensive analysis of the M. musculus TRIP13E253Q hexamer's conformation.
More quantitative growth curve analysis revealed that although all of the human HSF1 mutants identified promoted yeast growth, the HSF1 L189P mutant was somewhat more potent at activating yeast growth in comparison to the other mutants we identified.
RPE65-R91W transgenic mice are able transgenice somice1- cis-retinare(~10% of normable which leads to partially functional rhodopsin, and the rate of degenerateon in thisometant is somewhat slower than in the Rpe65-KO mouse.
