Sentence examples for mutants were refractory from inspiring English sources

However, in agreement with several studies which demonstrated that p53 mutants were refractory to reactivation to the wt p53 phenotype (Kern et al, 1992; Sigal and Rotter, 2000), transfection of wt p53 in the mt p53 cell line WiDr had no effect on sensitivity to TS inhibitors and TS activity, suggesting that the function of p53 could not be restored after transfection of wt p53 in mt p53 cells.

We found that the Ku80 mutant cells were refractory to the induction of MN by Tax while cells knocked out for DNA PKcs remained responsive to Tax induction of increased MN [ 6].

Gα12 mutants deficient in PC1 binding were refractory to PC1 inhibition of Gα12-stimulated apoptosis.

Importantly, compared to its wild-type counterparts HSF1S121A mutants not only exhibited higher basal transcriptional activities but also were refractory to AMPKαCA- and metformin-mediated suppression (Fig 3E and F).

For example, although set1 deletion reduced or eliminated a majority of DSBs across the genome, 22 DSB sites were refractory to this decrease, even showing an increase in DSBs in the set1 mutant (Borde et al, 2009).

But they also noted that hypnotherapy helped "even those whose conditions were refractory to other forms of therapy".

They were refractory to radiation therapy.

All 12 patients were refractory to lenalidomide; 10 (83%) patients were refractory to both bortezomib and lenalidomide.

However, several cases were refractory to plasma exchange combined with glucocorticoids (34.3 % refractory rate).

Therefore, if inhibition of LRRK2 kinase activity leads to decreased accumulation, then the A2016T mutant should be refractory to inhibitor with no change in accumulation.

This idea is further supported by the findings that suppression of Neu- and Ras-induced transformed phenotypes by Pin1 inhibition can be rescued by overexpression of a constitutively active cyclin D1 mutant that is refractory to the Pin1 inhibition [ 36].