We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers.
Additional genes involved in such synthetic interactions with ORC mutants are involved in cohesion [20].
Cyp2c70, downregulated in the liver of Dll1 mutants, is involved in linolenic and arachidonic acid metabolism.
The observation that numerous TS lethal, and not other TS mutants, are involved in protein synthesis, transport, or, as suggested by the current study, protein quality control (Table 4), implies that additional TS lethal mutants generated by Inoue and colleagues in Neurospora [4] may impact protein synthesis pathways.
Consistent with this, a high proportion of deregulated transcripts in esl1 Δ esl2 Δ mutants is involved in hexose transport, lactose transport, and carbohydrate metabolism (e.g., HXT13, HXT3, HXT6, HXT7, JEN1, HXK1, PGM2, MAL12, MAL32, and MAL33 ; Table 1), and should have been repressed under the high glucose conditions during the experiment.
Thirty-two targenesenes related to tall-culm mutant were involved on 14 chromosomes.
Fifty-one target genes related to dwarf mutant were involved in 18 chromosomes and 5 scaffolds.
In conclusion, osarf16, an auxin insensitive mutant, was involved in iron deficiency response in rice.
Microarray analysis showed that a large proportion of down-regulated genes in the abl1 mutant are involved in stress responses.
This set of mpk4 associated factors indicates that the mutant is involved in responses to both virulent and avirulent pathogens, and that the mutant has an expression profile like that of wild type plants treated with the hormone salicylic acid.
