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To determine whether the higher ABA levels observed in esk1 mutants were a direct or indirect consequence of ESK1 function, double mutants were generated with either aba3-1 or the ABA signaling mutant ost1/snrk2e.
Unlike the observations in Hexdact/+ embryos, Hexd+/−;Sox2Cre+/− embryos showed no change in the expression of T at 7.5dpc (Findicatingicathat thet the primitive streak defects of ablated mutants were a consequence of Hex-AVE ablation.
PINK1 B9 mutants were a kind gift from J. Chung.
In all experiments, miR-124 mutants were a transheterozygous combination of two independently generated alleles.
The only other mutations acquired in common by 1974M1 and at least one of these other mutants were a G to T transversion in the promoter regions of the ATP-binding cassette (ABC) genes spr1887 and spr1021 (Table 2, Figure 1).
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Gene engineering for generating targeted mouse mutants is a key technology for biomedical research.
The generation of targeted mouse mutants is a key technology for biomedical research.
And that's a shame, because, warts and all, this 12-movie franchise (not yet counting The New Mutants) was a gamechanger.
The 'Mutant Cure' implies that mutants are a disease and this story line has a disturbing similarity to the homophobic ex-gay movement, which promised to teach gays how to reject their homo 'illness" and become straight.'".
We do not suggest that Drosophila lam mutants are a model for mammalian laminopathies.
Our data strongly indicate that these mutants are a Drosophila model for WWS.
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