Sentence examples for mutants we show from inspiring English sources

Together with biochemical and crystallographic analysis of HD deletion mutants, we show that the HD is an autoinhibitory domain that blocks productive NAD+ binding.

In the case of cos2/kif7mw406 mutants, we show that early defects in Hedgehog signaling lead to a general, non-photoreceptor-specific delay of retinal neurogenesis, which in turn causes the secondary phenotype of delayed outer segment morphogenesis.

Here, using unbiased forward genetic screens, followed by analysis of reporters and engineered mutants, we show that stomatal initiation in the grass Brachypodium distachyon uses orthologs of stomatal regulators known from Arabidopsis but that the function and behavior of individual genes, the relationships among genes, and the regulation of their protein products have diverged.

Using conditional deletion mutants, we show here that c-Myc plays an important role in endochondral ossification and bone growth by promoting efficient proliferative expansion of both chondrocyte and osteoblast lineages.

Using DMPK mutants, we show that DMPK is required for a correct intracellular trafficking of insulin and IGF-1 receptors, providing a mechanism to explain the molecular and metabolic phenotype of dmpk−/− mice.

Finally, fourth, utilizing a panel of CXCL10 mutants, we show that the ability to inhibit endothelial cell proliferation correlates with CXCL10's glycosaminoglycan binding affinity and not with its CXCR3 binding and signaling.

Using the appropriate mutants, we showed that the discontinuous DNA synthesis observed in the lig mutant was not due to the occurrence of mismatch repair (mutS or mutL), nucleotide excision repair (uvrB5), or base excision repair (ung) (A130).

Using a series of engineered metal ion trapping mutants, we showed that the more compact of the two assemblies corresponds to an arrangement populated during activation of full-length receptors.

Using these mutants we showed that Mkk4 is dispensable for normal development and for host resistance to systemic bacterial infection.

By comparing expression of LHP1 targets in lif2, lhp1 and lif2 lhp1 mutants we showed that LIF2 can either antagonize or act with LHP1.

However, for the other three mutants, we showed that the conidia of female-sterile mutants were transferred significantly more efficiently than those of female-fertile strains.