Sentence examples for mutants we further from inspiring English sources

Using these UL54 deoptimized mutants, we further demonstrate that animals infected with the UL54-recoded recombinant virus exhibited decreased viral genome copy number in lymphocytes, reduced lymphoid atrophy and reduced tumor incidence.

By expressing MP in the epidermis of mp mutants, we further show that although MP activity in a single-cell layer is sufficient to promote polarity convergence patterns, MP in sub-epidermal tissues helps anchor these polarity patterns to the underlying cells.

In relation to the improvement of ASP-RNAi against the London-type APP mutants, we further observed that F-siRNA duplexes, F-siAPP(T12/C13), targeting the Swedish APP mutant carrying double nucleotide mutations, were able to markedly improve ASP-RNAi activity, although the conventional siAPP(T12/C13) duplexes induced little or no RNAi activity (Figure 4E).

As a first step toward understanding the molecular genetic processes underpinning sperm-transfer behavior and its regulation in C. elegans, and to establish a context to characterize sperm transfer mutants, we further defined this behavior.

Because we expected trafficking of otherwise normal proteins to be affected in p24 mutants, we further predicted that the Drosophila stress response would differ from that in yeast by more closely resembling the EOR rather than the UPR and that the response would be activated by the PEK or Ire-1 pathways.

By regulated expression of PPK1 from a tetracycline-inducible promoter in a ppk1 knockout mutant, we further demonstrated hysteresis in rel expression.

Because these phenotypic differences are present in the 5A CTD mutant, we further explored the possibility of abnormal DNA content using flow cytometry.

Therefore, taking advantage of the dominant negative effect of ANXA2Y23A, and employing this ANXA2Y23A mutant, we further demonstrated that EMT is induced by TGFβ in cells expressing ANXA2WT, but not in cells expressing ANXA2Y23A (Figure 3D).

Based on the result with the K356D mutant, we further propose that this anchoring serves to stabilize, compartmentalize and activate SpoIIE, and that these activities are linked through a common feature of SpoIIE.

Since our data have shown the genotype-depended divergences of stress-induced behaviors in the mixed back-ground wild type, Per1 mutant and Per2 mutant mice, we further investigated the mRNA expression profiles of several stress-related genes (Crh, Avp, Oxt, c-fos and Nr3c1, which is the encoding gene of glucocorticoid receptor) and Per genes in PVN of all strains.

There was no alteration in acute chemical (formalin) induced nociception in our mutant, therefore we further hypothesize that HDAC4 regulates thermal nociceptors specifically, as has been described for Runx1.