Examining 48 additional tyr a chromosomes in albino mutants, we found evidence of historical recombination between thrsp and tyr in only 12 cases.
When applying the same analysis to several barnase mutants, we found that single mutations may drastically change the free-energy landscape and may significantly alter the population of the two minima.
Employing a biologically relevant experimental model consisting of cells expressing R75C, R519C, R789C, and G853E procollagen II mutants, we found that the R789C mutation causing a decrease in the thermostability of collagen not only alters individual collagen molecules and collagen fibrils, but also has a negative impact on fibronectin.
Using a series of ERalpha mutants, we found that helix 12 was not required for the binding of CoRNR box peptides, whereas disruption of helixes 3 and 5 had a marked effect on peptide binding.
In all mutants, we found that asexual development, spore formation and spore germination were indistinguishable from those of wild-type strains.
When we measured constitutive activity in all the EL1 mutants, we found that E100A, D122A, and S127L, had higher constitutive activity than the wild-type MC4R (Table 1).
By examining the morphology of motor neurons in the mutants, we found that some VD neuron axons showed defective morphology in several mutants (Figure 1C and Table 2).
Through the study of a large panel of transgenic mice expressing many different PrPC mutants, we found that the toxicity of PrPC deletion mutants was abolished by removal of the GPI anchor [42].
When we tested the cleavage resistance of V5-MKK7cr_45 V5-MKK7cr_77r_77 mutants, we found both of the mutants were resistant to the cleavage in CHO K1 cells (Figure 2F).
Among these mutants, we found that the offspring of E. coli lacking Lpp [9] decreased in 4-cell array population; besides, the interaction force between the bacterium and agar was smaller compared with the case of the other mutants.
Among 36 LTM mutants, we found three strains with optomotor responsiveness as high as dunce mutants, namely D0264, D0067, and D0177 (named Rafael, Norka, and Toi, respectively, in the publication where they were first described [8]).
