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Thus, using these two mutants, we could test the relative importance of accumulated cyclin D1 cdk4 complexes.

Therefore, we hypothesized that by lowering the level of cdc-42 in mir-83 (n4638 ); mir-34 (gk437 ) mutants we could suppress the gonad migration defect.

Moreover from the analysis of single and multiple mutants we could rule out the involvement of a group of DOF proteins, known as CDFs, already characterised for their involvement in flowering time, in the regulation of AtMYB60 expression.

As occurred with the previous two deletion mutants, we could demonstrate no Ego1 requirement for relocating Gln3-Myc from the nucleus to the cytoplasm when glutamine was added to re-feed the nitrogen-starved and nitrogen-limited cultures.

In support of a GH-independent mechanism for altered IGF1 levels in the mutants, we could not detect GH in serum of WT or mutant animals at P9 (data not shown).

For the mutants, we could not ascertain the angles of stumbling, but the load dependence suggests that the mutants also tend to dwell at ∼80° ahead of ATP-waiting angles.

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Similar(53)

Consistent with a severe defect in a null-mutant we could not obtain viable LplA1 parasite clones, indicating that LplA1 has a crucial function in Plasmodium during their intraerythrocytic life and that development of LplA1 inhibitors has potential for future drug discovery.

With the aid of the adg1-1/tpt-2/gpt2-1 triple mutant we could demonstrate that GPT2 is not involved in the survival of the double mutant.

As shown in Figure 5D, with the SptP mutant, we could detect an increase in actin coimmunoprecipitated with villin, indicating that villin phosphorylation affects its actin binding capacities.

Because of the instability of the Trp346Tyr mutant, we could not conclusively assign this resonance and thus used paramagnetic relaxation enhancement (PRE) to aid us in assigning this resonance.

In the rpd3 mutant we could not discern any changes in histone H4 or H3 acetylation levels compared to wild-type over the entire FLO1 upstream region tested (Fig. 6B and C, rpd3).

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