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From results obtained with all Walker motif mutants, we conclude that the assembly of TClpB monomers into the ring oligomers is driven by nucleotide binding to AAA1, while nucleotide binding to AAA2 governs the correct assembly into hexameric rings.
Because hermaphrodites in these assays were genetically immobilized unc-31 (e169) mutants, we conclude that the difference in male response was not due to changes in hermaphrodites locomotory behavior, as described by Kleeman and Basolo (2007).
Since the distributions of the First Maximum are the same for the wild type and mutants, we conclude that the smaller steady-state level of nuclear NF-кB concentration infers stronger negative feedback.
Using histology, molecular markers and analysis of Celsr1 and Vangl2 mouse mutants, we conclude that though both are obligatory for normal lung development, these proteins regulate some distinct steps in airway formation.
In view of the viability and the fact that sec8 is almost completely deleted in sec8Δ1 mutants, we conclude that sec8P1 represents a hypomorphic allele, while sec8Δ1 represents a zygotic null allele.
From the analysis of spontaneous and induced Sal-resistant mutants, we conclude that a single substitution in an RNAP subunit gene, either rpoC or rpoB, is sufficient to confer Sal-resistance, and we infer that RNAP is the functional cellular target for Sal.
Similar(52)
Because the leaf phenotype of gns4 was not as stiff as those of the d11 1 and d11 2 mutants, we concluded that gns4 was likely to be a weak mutation of D11.
Since we only observed strong repression in dendrite development in slmb mutants, we concluded that slmb shares the reduced branching phenotype seen in CSN5, Nedd8 and cullin1.
Based on the flowering behavior of the double aba2 ga1 mutant, compared to the respective single mutants, we concluded that the block in ABA and GA synthesis, respectively, result in independent phenotypic effects on flowering time.
Based on these results and additional analyses (data not shown) of the adapted mutants, we concluded that #7 was the best performer of all candidate strains and the remainder of our research focuses on this strain.
These results clearly confirm the primary role of Rv1208 in the initiation of MGLP synthesis, however, since residual amounts of MGLPs were still produced in the mutant, we conclude that another enzyme displaying glucosyl-3-phosphoglycerate synthase or glucosylglycerate synthase activity contributed to the pool.
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