Sentence examples for mutants vulnerable to from inspiring English sources

In A. fumigatus, genetic deletion of a polyketide synthase involved in pigment biosynthesis (PksP) results in surface exposure on resting conidia, rendering the PksP mutants vulnerable to efficient macrophage phagocytosis [24], [26].

Overexpression of mutant EphA2, vulnerable to cleavage, led to cell cell repulsion only when MT1-MMP was also expressed.

We hypothesized that formation of the Tim9 Tim10 complex shields the small Tim proteins from degradation and the Tim9 mutants leave Tim10 vulnerable to degradation because the mutant complexes are unstable and/or more dynamic than the WT complex.

The reduction of DARPP-32 expression in the striatum of old rats, induced by a lentiviral vector encoding mutant Htt, indicates that these rats were more vulnerable to mutant Htt than young animals.

There are mainly two hypotheses that could explain adult onset in HD: Either mutant Htt progressively produces cumulative defects over time or "normal" aging renders neurons more vulnerable to mutant Htt toxicity.

Behavioral analyses revealed no differences from wild types, but mutant mice were more vulnerable to kainate-induced seizures.

"Normal" aging may render striatal neurons more vulnerable to mutant Htt toxicity.

Transcripts derived from three of these mutant PALB2 alleles were vulnerable to nonsense-mediated decay.

Nitric oxide synthase (iNOs) mutant mice are more vulnerable to some types of infection than wild-type mice [ 21].

Regarding HD, the disease has long been known to be caused by an expanded polyglutamine tract in the N-terminal domain of the huntingtin protein, but the mechanisms by which MSNs are highly vulnerable to mutant huntingtin are still incompletely understood.

The mutant with a higher copy number was vulnerable to invasion by another mutant that had higher copy number, which in turn was vulnerable to invasion by another mutant with still higher copy number and so on.