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Last year, after rumors began to circulate that Burning Man would again be placing restrictions on the musical goings-on, organizers merely required mutant vehicles to restrict their movements to a "deep-playa music zone," at a remove from those attending the festival to see art or hang out with their small children.
Most of these studies have used constitutively active (CA) and/or dominant negative (DN) mutations, generated by direct mutation of the conserved domain to restrict mutant GTPase proteins to the active GTP-bound form (constitutively active) or inactive GDP-bound form (dominant negative).
To restrict resistant mutants, the optimal dose needs to be selected in view of the maintenance of a trough concentration above the MPC.
In present study, a correction is required when concentrations are high enough to kill the resistant (the cefquinome concentration needed to exceed the MPC for over half the dosing period to restrict the recovery of mutants).
APOBEC3G was discovered by its ability to restrict replication of a mutant HIV-1 lacking the viral infectivity factor (Vif) (Sheehy et al. 2003).
| Regulators to restrict payday lending.
"A campaign to restrict contraband?
Try to restrict drinking to special occasions.
One way to vet these candidates is to develop mutants that restrict conformational landscapes.
In summary, all these observations supports the notion that the muscle defects in lin-12 mutants appear to be restricted to the postsynaptic development in the vm2 cells.
We were curious to know if the elongation defect in exocyst mutants was restricted to the elongation zone, or if it represented a more generalized defect (for example, a defect altering the basic structure and overall expansibility of the cell wall) that also influenced cell elongation in the meristem.
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