Sentence examples for mutants to function from inspiring English sources

The ability of Chk1 mutants to function proficiently with minimal levels of phosphorylation is not unprecedented.

Our observations provide a molecular mechanism explaining the failure of previously described N-DAT mutants to function in vivo.

We first investigated the ability of the deletion mutants to function as primary cellular receptors for human adenovirus serotype 5 (Ad5).

This suggests that the incapability of the IKK2mono I413and414A and V229A/H232A mutants to function as IκB kinases results from their inability to support activation via trans autophosphorylation.

Using live single cell imaging, we were able to use these mutants to analyze functions of the C-terminus in chemokine-induced Ca2+ responses and heterodimer formation.

The crystal structure of the complex allowed us to learn more about the requirements of the interaction and to find mutants suitable to function as constitutive GTPase-negative Rap variants, as we have previously shown that the G12V mutation of Rap1 is still responsive to GAP-mediated GTP hydrolysis.

Figure 4 shows that the polymorphic population neutrally evolved to a markedly higher mutational robustness than the monomorphic populations, with 50±2%2% of the final polymorphic population mutants continuing to function versus 39 ± 2% for the final monomorphic populations (Chi-square P-value of 10-3 thesethese values are the same).

The mechanism we have identified here may also underlie the ability of wild-type or mutant p53 to function as co-factors in order to regulate other target genes whose promoters lack a p53 consensus sequence.

Quantifying the CYH2 pre-mRNA/mRNA ratio in transformants carrying the upf3 alleles revealed that the ability of the mutant proteins to function in NMD ranged from 27%to87%7% compared to wild-type Upf3p (Table 1.

While the use of single-gene mutants to elucidate gene function is a powerful tool, many authors have cautioned that the methods by which these knockout animals are prepared may not reveal the true contribution of the knocked out gene to the transcriptional profile compared with "control" animals [19], [20], [21].

Thus, proteomic identification of RNA-binding regions (RBR-ID) is a powerful tool to map protein-RNA interactions and will allow rational design of mutants to dissect their function at a mechanistic level.