Sentence examples for mutants to elucidate from inspiring English sources

In our efforts to delineate the function of Rest during neural development, we generated several Rest deficient ES cell mutants to elucidate the role of Rest in the transition from pluripotent ES cells to multipotent NSCs and subsequently to mature neurons.

While the use of single-gene mutants to elucidate gene function is a powerful tool, many authors have cautioned that the methods by which these knockout animals are prepared may not reveal the true contribution of the knocked out gene to the transcriptional profile compared with "control" animals [19], [20], [21].

This research might include the use of mutants to elucidate the cellular and molecular processes that control normal eye development and function and to provide models for the investigation of the genetic bases of inherited eye diseases.

Work in A. thaliana has made extensive use of high throughput sequencing in combination with sRNA silencing mutants to elucidate the roles of genes within the different biogenesis pathways for sRNA classes [ 6].

An L. major mutant deficient in all three ISP genes (Δ isp1/2/3) was generated and compared with Δ isp2/3 mutants to elucidate the physiological role of ISP1.

It will be exciting to map where hybrids form in RNase H, sen1-1 and srs2Δ mutants to elucidate whether these different anti-hybrid systems are dedicated to protect different regions of the genome.

We therefore focused on the pex4-1 mutont to elucidate the molecular changes in peroxisome function that accompany growth at high temperature.

Identification and characterization of enhanced disease susceptibility (eds) mutants, including a series of phytoalexin deficient (pad) mutants, have helped to elucidate a number of defense signaling pathways involved in both basal and induced defense responses [ 19- 21].

Further characterizations of these escape mutants are required to elucidate the mechanism responsible for this phenomena.

Future transcriptomic and proteomic studies on the mutants may help to elucidate the pathways involved and define the roles of these genes in more detail.

In addition, quantification of in vivo cGMP transients with fluorescent cGMP-reporter assays in wild-type or selected mutants will help to elucidate the biological role of novel GCs.