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And although many of these are harmless, amongst the myriad mutants there are those whose effects are anything but benign: subtypes 6 and 11 can lead to genital warts; subtypes 16 and 18 (amongst others) can lead to cervical, vulvar, vaginal, penile, anal and oral cancers.
At his private school, Xavier's School for Gifted Youngsters (and before you giggle, that name is right out of the comics, too), where he houses and trains young mutants, there are cameos by X-Men like Bobby Drake, the Iceman.
As mentioned in the Introduction, despite detailed studies of single and multiple adenylyl cyclases mutants, there are still cAMP-dependent developmental processes where the respective contribution of these enzymes is not clear.
This analysis showed that, while there are 3 5 Zn5+ cells every 20 µm in WT and des mutants, there are 1 9 in srn and dla, and 0 3 in mib, confirming our visual impression that patterning is aberrant (Fig. S5E F).
For mibta52b mutants, there are 61 (32 up-regulated and 29 down-regulated) genes common to all three time points, and 1821 11288 up-regulated and 693 down-regulated), 49 (14 up-regulated and 35 down-regulated) and 1851 9300 up-regulated and 921 down-regulated) genes specific at 24 hpf, 48 hpf and 72 hpf, respectively (Figure 3E and 3F; Table S12, S13, S14 and S15, q = 0.0).
In both the Fn1 and Itga5 mutants, there are mesoderm defects, in the notochord and somites.
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For both mutants there was altered expression of genes involved in nucleotide biosynthesis at the non-permissive temperature.
In addition, in brm mutants there is an increase in the amount of H3K4me3 at the FLC locus, as was previously shown for the fve and fld mutants [27], [60].
In the mutants there is a strong bias for UNC-40 GFP UNC-40 GFPocalized to the dorsal region.
In the library of 100 random mutants there were 49 independent mutants detected with a total count of 102 recurrent mutations, which is a higher proportion of recurrent mutations than was expected [ 5].
The long-lived skn-1 mutant also expresses high levels of antioxidant enzymes [ 131- 133], and in clk-1 mutants there is a significant increase in detoxification enzymes including UDP-glycosyl transferases, glutathione S-transferases, and SOD-3 [ 163].
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