Suggestions(5)
Exact(7)
Of the four mutants, the double mutant K312E/E539K had the greatest performance.
Surprisingly, in a recent study on site-directed mutants, the double mutant Y143R + N155H exhibited a selective advantage over other mutants in the presence of RAL [20].
When mad2 Δ mutant was analyzed with msh4 mutants, the double mutants mad2 ∆ msh4 –R676W and mad2 Δ msh4 Δ showed viability of 27 and 10%, respectively.
Examination of ABH/OG stained full-length tibia sections revealed that skeletal elements of the Rbpjk mutants, the double heterozygous and the Rbpjk mutant/ Sox9 haploinsufficient embryos were all significantly smaller than littermate controls and displayed bowed skeletal elements.
When combined with the heat sensitivity of the uvh6 mutants, the double mutants are hypersensitive to heat stress at the cellular level but do not exhibit additional heat-induced growth inhibition.
When APP mutant mice were crossed with P301L tau mutants, the double mutants exhibited a substantially enhanced NFT pathology in the limbic system and olfactory cortex compared to the single transgenic P301L tau mice, despite similar levels of tau expression [ 55].
Similar(53)
Under rich growth conditions the amino acid levels of WT cells, ESCRT mutants, autophagy mutants and the double mutants are comparable.
We further observed that loss of tej and tap together results in more severe defects in the piRNA pathway in germline cells compared to single mutants: the double-mutant ovaries exhibit mis-localization of piRNA pathway components and significantly greater reduction of piRNAs against transposons predominantly expressed in germline compared to single mutants.
Rosette size of all single mutants and the double mutants xi-1/xi-2 and xi-1/xi-k was similar to that of wild type and was not investigated further.
Wild type ADNP, the single point mutants and the double mutant were fused to YFP and stably transfected in NIH3T3 cells using an inducible system.
The two single mutants and the double mutant did not significantly differ from each other (p > 0.178).
More suggestions(15)
mutants the developmental
mutants the initial
mutants the maladaptive
mutants the small
mutants the β1-integrin
mutants the anterior
mutants the nodule-specific
mutants the tetrameric
mutants the mutant
mutants the prevailing
mutants the green
mutants the functional
mutants the myocardial
mutants the average
mutants the two
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