DOI: http://dx.doi.org/10.7554/eLife.06306.011 Because the synthesis of many membrane proteins was affected in dPob mutant cells, we observed the phenotype of dPob mutant throughout the developmental processes of photoreceptors.
Although the initiating event would be different (and currently unknown) from the WT1-mutant subset, the developmental stage at which this initiating event would occur would be the same as in WT1-mutant tumours.
The sucrose content in fibers of TM-1 was higher than that in the im mutant during the developmental interval 25 ~ 35 DPA, which corresponded to the difference in cellulose content between the two accessions.
Of the 38 probe sets annotated as Ces or Csl, only 1 probe set, GhiAffx.58712 demonstrated reproducible >2 fold altered gene expression in the Li 1 mutant at the developmental stages analyzed.
While the A94fs199X-hSyn II mutant, due to the lack of expression, implies a full loss-of-function, the ability of the missense SYN2 mutants to rescue the developmental phenotype of SYN2 KO neurons is testable.
Studying eggs that arise from these mutant oocytes assesses the developmental impact of the mutated motor.
The previously unreported faster maturation of MAPT mutant human neurons, the developmental expression of 4R tau and the morphological alterations may contribute to disease development.
To begin to investigate the relationship between H3K9me2 marks and WAGO-1 activity, we generated a wago-1 (0); met-2 (0) double mutant and evaluated the developmental phenotype.
In addition, human infratentorial and supratentorial low-grade gliomas have distinct expression signatures corresponding to normal astrocytes and NSCs from their respective regions [ 20], while the expression patterns of G34R/V and K27M mutant gliomas mimic the developmental region in which they arise [ 8].
Because strong unc-112 mutants are very sick and develop extremely slowly, we performed our unc-112 epistatic studies in a dim-1 mutant background that suppresses the developmental delay of unc-112 mutants but has no visible effect by itself on engulfment (Table 1).
