Exact(39)
Among the 23 mutants that we constructed, the most promising Y216W showed an 18 ± 2.7% increase in specific activity by comparison with the wild type enzyme.
Heck, even if GDP shrank an impossible-to-imagine 10percentthathat would take us back to the dire wasteland of warlords and mutants that we last suffered through in [checks notes] er, 2013, which didn't seem like such a dystopia at the time.
In addition, 8 mutants that we detected were found in different ethnic backgrounds.
The observation that Δprocyclin is notably more robust than other procyclin mutants that we have generated previously is most probably because of the experimental strategy that was used.
This observation suggests that, early in the period of evolution, the cheating mutants that we see are those that are able to gain a foothold in the population from an initially low frequency.
Nonetheless, despite a large false positive rate in the primary screen, 68% of the mutants that we subjected to further study were confirmed to dysregulate innate responses of primary macrophages.
Similar(21)
From our previous study on RNA biogenesis mutants that induce hybrids, we noted that many of these mutants allow cryptic transcription, and likely the production of aberrant transcripts (Wyers et al., 2005; Cheung et al., 2008; Wahba et al., 2011).
Still, when we focus on the mutants that show high-aggregation propensities, we find that the majority of patients with these mutations exhibit a rapid disease course.
In my own work with particular Arabidopsis mutants that are mostly sterile, we do see revertant sectors, albeit rarely.
However, in the ovaries of mutants that affect genome stability, we do observe reporter activation outside of the germline and this observation provides us with important insights.
Besides the in vitro isolated mutants that have panD mutations, we also found panD mutations in clinical isolates such as M. canettii and a clinical strain.
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