Sentence examples for mutants that remove from inspiring English sources

The Clandinin lab created mutants that remove both Ncad and the recently characterized N-cadherin2 (Ncad, Ncad2 double mutant, hereafter called NcadΔ14) [55].

We propose that the vast majority of nonsense mutations that affect all three basic dumpy phenotypes are in constitutive exons, whereas nonsense mutants that remove only one or two of the basic functions are in alternatively spliced exons.

To explore the functions of the members of the miR-2 family we have generated mutants that remove miRNA function.

Assessment of the evidence suggesting that depletion of miR-2 and miR-13 group miRNAs results in embryonic apoptosis, should await functional characterization of loss-of-function mutants that remove their functions in vivo.

Deletion mutants that remove residues contributing to the cleft (e.g., Plin2-I) would also be expected to differ in binding interactions and affinity, as was observed with the experimental data demonstrating higher affinity for stearic acid than cholesterol with deletion mutant Plin2-I and decreased affinity for cholesterol when compared to the full-length protein.

The levels of p-ERK and p-AKT seen in these mutants (lanes 7 and 12) match those of the empty vector (Control, lane 1) and the truncation mutant that removes both D1 and D2 phosphatase domains (lane 10), implying that point mutations R1608Q and R1384Q are complete, de-activating mutations.

The H242A variant is an M-site deletion mutant that removes one of the two histidines necessary for tight binding of copper to the M-site.

Interestingly, all double and triple mutant combinations that changed the preceding aspartate D223 together with E224A or E224Q restored viability, including a triple mutant that removed all acidic residues from the Cdc6 DEMD Walker B motif.

b) We have found the quadruple knock out of PP2C protein phosphatases leads to constitutive Ca2+-signaling and ion channel regulation in planta, a major finding that provides a first mutant that removes the requirement for ABA-induced Ca2+ sensitivity priming.

To simulate and understand these properties are especially important for metabolic engineers to design mutant strains that remove these regulatory mechanisms that protect microorganism from over-production to increase yield of amino acid production.

In the present study, two TL mutants were designed that remove the symmetry of the sequence repeats and ensure that either the bifurcated or the elongated-rod conformation is thermodynamically favored.