Sentence examples for mutants that prevent from inspiring English sources

Entrainment of circadian behavior to daily temperature cycles presented in constant darkness was largely unaffected in mutants that prevent splicing of the terminal per intron (Additional file 6).

The structure reveals the intricate mechanism by which MO25β binds to MST3 and enables the construction of mutants that prevent activation of MST3 by MO25β.

Formally, checkpoint deficiency in the presence of mutants that prevent the phospohorylation of the MELT motifs might be due to the impaired binding of MELTP-binding proteins other than Bub1 Bub3.

Thus selecting for mutants that prevented substrate transport but which still allowed substrate binding with an affinity similar to the wild type transporter would result in a transporter with properties more suitable for structural studies i.e. biased towards a single conformation.

Due to partner matching defects in the ten-a mutant that prevent clear delineation between the two glomeruli, the combined count was compared across genotypes.

On the contrary, the Y372F mutant that prevents human ZnT3 oligomer formation showed basal zinquin staining similar to non-transfected cells (Fig. 5C).

The impact of RalA knockdown on granule docking was comparable to that obtained after introduction of a dominant negative Sec mutant that prevents the assembly of the exocyst complex [14].

The FGF14bR/A mutant that prevents interaction with the NaV C-terminus cannot rescue NaV kinetic effects of FGF14 knockdown.

One possibility is that there exists a latent (knockin) role for this particular F deletion in the CFTR mutant that prevents its own clearance.

"It" is a series of negative results discussed in the previous lines and showing that a point mutant that prevents binding of the CT has no effect in vitro and in vivo on microtubule depolymerization.

Our in vitro studies also suggest that a potential mechanism of resistance in patients with RAS mutant tumors being treated with pan-RAF drugs is acquisition (or selection for cells with pre-existing mutations) of a CRAF mutation such as a gatekeeper mutant that prevents drug binding.