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We carried out a mutagenesis screen to identify mouse mutants that might possess muscular defects on the basis of exhibiting reduced grip strength.
Our findings demonstrate significant differences in the immune response profiling of Wt α-Syn and PD-related mutants that might indicate the existence of different pathways towards PD onset and progression.
In contrast to these mutations that led to a decrease in the specificity of the ERK2-Ets interaction, the modeling also allows for a prediction of potential mutants that might improve specificity.
Due to personnel availability and technical issues, construction of the various double mutants that might include yfjK and testing them would require several additional months.
In an anatomical screen examining mutants that might be involved in synaptogenesis, we identified a weak hypomorphic mutation (R561H) in the kinesin-3 family member Unc-104.
Finally, according to our model, certain HEGs might be stable in the short term but not in the long term, in the sense that particular mutants that might lead to extinction of the HEG can invade the population.
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We believe, however, that there should be additional pathogen factors that influence activation of systemic immunity because Drs was not completely abolished in the single mutants, although that might have been the case in a SAP4, SAP6 double mutant.
Based on published analyses of some of the mutants, that defect might involve an altered interaction with TFIIF.
Another class of mutant animals that might fail to be identified by this screen are mutants that cannot sense food or a chemical odorant.
"If you have the mutant gene, that might be co-expressed with favourable components of the human genome.
In a search for mutant mice that might be missing the gene, Banfi and colleagues came upon a strain called head slant.
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