Sentence examples for mutants that interfere from inspiring English sources

Mutants that interfere with TBK1 dimerization show significantly reduced trans-autophosphorylation but retain the ability to bind adaptor proteins through the CTD.

To understand the relevance of indolic or total glucosinolate contents on Lepidopteran herbivory, mutants that interfere with biosynthesis of these compounds, in combination with the myb28myb29 mutant, should be explored.

It is also possible that loss of CTDK-I function may promote RNAPII "stalling" during transcription elongation and similar to other THO mutants that interfere with transcription elongation, promote the formation of recombinogenic DNA RNA hybrids [74].

However, in HCT116 cells expressing knock-in mutants of STAT3, a STAT3 phosphorylation mutant that interferes with DNA interactions consistently enhanced the basal levels of BMF, whereas a STAT3 acetylation mutant had less impact on the target gene (Supplementary Figure 9b).

Taken together, these data show that we have identified a new class of spt16 mutants that interferes with Spt16 activity specific to its role in transcription-coupled nucleosome assembly rather than its generally required functions in transcription, cell viability, and/or DNA replication/DNA repair.

There is no data in the paper addressing this issue and previous data from one of the authors assessing the function of a mutant that interferes with this interaction was assessed to cause defects in mitosis rather than replication.

These data suggest that pathogenesis involves the extracellular mutant proteins that interfere with the normal structure or function of basement membranes.

Since K48- and K63-linked chains assemble early in the NF-κB pathway, one could speculate that transgenic animals expressing mutant isoforms of ubiquitin that interfere with chain assembly in a dominant negative manner (K63R or K48R mutant ubiquitin) would display disrupted NF-κB activation and, thereby, survive the induction of endotoxic shock induced by LPS.

The gene — which was discovered, in 1989, sitting out on the long arm of chromosome No. 7 — produces a mutant protein that interferes with cells' ability to manage chloride.

Our ITC data are further supported by the identification of point mutants of HSP70 and DnaK that interfere with the binding of PES and PET-16, as presented below.

In the past, most of these have involved pathogen-derived resistance strategies such as the expression of mutant or truncated viral proteins that interfere with virus infection, or transcription of viral RNA sequences that silence the expression of virus genes.