Sentence examples for mutants that impact from inspiring English sources

Thus a relatively random selection of TS lethal mutants has led to a group of mutants that impact various steps of the protein synthesis, trafficking, and quality control suggesting that this might be a common characteristic of the TS mutants in Neurospora generated by Inoue and colleagues [4].

Since diploid mutants have a chromosome homolog in G1, they are radioresistant throughout the cell cycle and thus facilitate the detection of previously unknown DSB repair gene mutants that impact checkpoint and/or recombinational repair functions in G1 or early S phase prior to the completion of DNA synthesis.

Therefore, to address whether regulation of Rps6 is by either TORC1 or TORC2 or both, we examined its phosphorylation in mutants that impact upon the function of each complex.

To identify unknown genes that contribute to improved xylose fermentation in these recombinant S. cerevisiae, we performed genome-wide synthetic interaction screens to identify deletion mutants that impact xylose utilization of strains expressing the xylose isomerase gene XYLA from Piromyces sp. E2 alone or with an additional copy of the endogenous xylulokinase gene XKS1.

In an attempt to isolate such proteins, we performed genome-wide synthetic genetic array (SGA) screens (Tong et al. 2001) to identify deletion mutants that impact the xylose utilization of strains expressing the XI gene XYLA from Piromyces sp. E2 (herein referred to as pXYLA) and strains expressing both XYLA and an additional copy of the endogenous XK gene XKS1 (herein referred to as pXYLA, XKS1 ).

This was distinct from the phenotypic observations with respect to other mutants that impacted courtship behaviors, in that the phenotype of the fru mutant was specific to courtship behaviors.

This suggested either rasl11b expression in mesoderm could be restricted by Oep in a manner different from Nodals, or Zoep embryos could have a particular Nodal signal level, different than in Nodal mutants, that had the opposite impact on rasl11b expression.

On the other hand, we used a data set of mutants that do and do not impact protein stability.

The motivation is that designing a test case to exercise a large program path that includes integrated units, or analysing a mutant that has wide impact on join point quantification, is very likely to require effort and complexity that cannot be easily quantified only in terms of the number of test cases or the number of test requirements.

Additionally, given that we evaluated single-point mutants, the impact of combinatorial modifications in the substrate could not be readily assessed from our approach.

To extract the relation between mutants and impacts we say that when an impact is found, the closest mutants all have that impact.