Sentence examples for mutants that generate from inspiring English sources

The results show that CyPrP generated from GSS PrP mutants does not aggregate in the cytosol and thus, aggregation cannot be responsible for the loss of anti-Bax function in the GSS mutants that generate CyPrP.

A major challenge in studying achiasmate chromosome segregation mechanisms is that most of the mutants that generate natural nonexchange chromosomes have very poor spore viability.

The APCMin/+ mutation, which results in high levels of β-catenin, predominantly causes intestinal polyposis, while APC mutants that generate intermediate levels of β-catenin preferentially induce mammary tumors [ 95].

Most importantly, we observed that the GSS-associated mutants that generated significant levels of CyPrP and prevented condensed chromatin could not prevent caspase activation.

We also identified a number of cell lethal mutants that generated wild type twin spots but no apparent corresponding mutant clone, implying that recombination had occurred but that the mutant cells did not survive.

We further examined five potential off-target sites from three groups of F1 white-eyed mutants that generated from Cas9 nickase and pairs of sgRNAs.

These predictive computational methods use single or multiple inputs for example, protein sequence signatures, protein protein and genetic interactions or mutant phenotypes for algorithms that generate annotations for gene products in an unbiased manner.

The incremental strategy would prioritize, initially, the use of the operators that generate mutants that were not detected by FindBugs and have a lower cost in terms of the number of generated mutants.

No differences in splice site scores were observed between wild-type and 648T>A or 1250C>T transcripts or between wild-type and mutant transcripts that generated low exogenous protein expression.

Therefore, the loss of anti-Bax function in PrP mutants can occur through two mechanisms: low levels of CyPrP through decreased retrotranslocation or pre-emptive quality control and loss in anti-Bax activity for those mutants that can generate CyPrP.

In those mutants that did generate detectable CyPrP, most of the CyPrP likely resulted from retrotranslocation because CyPrP migrated at the expected size for deglycosylated PrP lacking the N-terminal or C-terminal signal peptides.