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A population genetic analysis of microsatellites showed the existence of resistant mutants that evolved from originally susceptible strains, different cyp51A mutations in the same strain, and microalterations in microsatellite repeat number.
Early stage studies on bevirimat׳s mechanism of action were focused largely on extensive characterization of bevirimat-resistant mutants that evolved during serial passage of HIV-1 at a suboptimal drug concentration.
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The fact that most of the mutants that have evolved in these lineages were able to persist in time could be a consequence of the mutational resiliency that evolved owing to the short Hamming distance values.
That evolved into recording".
That evolved into working on accessories.
Are Millennials really that evolved?
Wonder how that evolved....[10]....[10]
Analysis of E1 genes in this study suggests that virus strains in Papua New Guinea are closely clustered with mutant strains that evolved in India and subsequently spread to other countries, such as Malaysia, Singapore, Sri Lanka, Thailand, and Italy.
Additionally, the sensitive detection of HBsAg mutants that continue to evolve due to vaccine escape, immune selection and an error prone reverse transcriptase is a necessity.
Taken together, we predict therefore that nonproducing residents will be more easily invaded, that resistance of the invader to inhibitory toxins is more likely to evolve when invaders are at a high starting frequency and that resistant mutants that evolve will be more likely to invade in unstructured environments.
This hitherto unrevealed extensive variation in B-cell antigenic regions suggests a still undisclosed complex scenario of dynamic antigenic profiles for this unavoidable pathogen's antigen, likely representing new neutralization escape mutants that continue to co-evolve with the human host.
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