The allelically variant feature that correlates with susceptibility to these DM effects is low affinity for CLIP; DM-dependent changes in abundance are reduced by invariant chain (CLIP) mutants that enhance CLIP binding to class II.
Selection on host modifiers is sexually antagonistic in that, conversely, host mutants that enhance Wolbachia in females are favoured whereas suppressors are not.
Using a population genetic model, we investigate the spread of host mutants that enhance or repress Wolbachia action by affecting either bacterial transmission or the level of CI.
We performed a genetic screen for mutants that enhance the weak dauer-constitutive phenotype of an ak t-1 null mutant (eak screen).
That condensin II, and in particular the Cap-H2 condensin subunit, is important for functional trans-interactions is evidenced by Drosophila mutants that enhance transvection (Hartl et al. 2008a).
Using GFP-tagged receptors and mutants that enhance or eliminate β-arrestin association and internalisation, we show how NPY-induced changes in receptor diffusion are clearly correlated with activated receptor targeting to arrestin dependent endocytosis mechanisms.
However, constitutively high expression of mutants that enhance TP53 activity is associated with increased tumor resistance and premature aging (Tyner et al., 2002), whereas an additional single copy of wild-type Trp53 gene under endogenous gene context (on a BAC) gained the transgenic animal tumor resistance without compromising longevity (García-Cao et al., 2002).
CHMP4A filaments also remain flat when built from a constitutively 'open' CHMP4 α1 α5) truncation mutant (Shim et al., 2007; Figure 4B) or a K52E mutant that enhances Snf7 assembly in yeast (Henne et al., 2012) (not shown).
DOI: http://dx.doi.org/10.7554/eLife.00184.008 Giant liposome patching was employed to assay the functional properties of both wild-type GsuK and L97D pore mutant, a mutation that enhances the channel conductance and open probability (Shi et al., 2011), and also yields better diffracting crystals ('Materials and methods').
Importantly this result reinforces the conclusion from analysis of Δ5'+neo and SPA+neo mutant ES cells that enhanced sense transcription initiated upstream of Xist antagonises Xist promoter methylation.
