Sentence examples for mutants that decrease from inspiring English sources

Slaymaker et al. created systematic single or multiple mutations in the positively charged residues that are predicted to be involved in the interaction with the non-target strand of the target DNA and identified Cas9 mutants that decrease off-target effects without impairing on-target activity (Slaymaker et al., 2016).

We show that host mutants that decrease CI-levels in males (e.g. by reducing Wolbachia-density during spermatogenesis) spread, even at cost to mutant males.

The observation that both mutants that decrease autolysis (altA, opuD, purA, 123 D2) and increase autolysis (fmtA, graS, imp) have biofilm defects suggests that the timing of autolysis and the accumulation of eDNA in the biofilm matrix may be critical in biofilm development.

The availability of mutants that decrease substrate specificity of T7 RNAP further broadens the range of chemically modified NTPs used as substrates for RNA synthesis.

Mutants that decrease HAT activity (PKM and KQL) show similar MPA sensitivity to cells lacking Gcn5 while a HAT domain mutant that does not affect HAT activity (PKE) shows higher levels of MPA resistance.

All mutants that exhibited decreased cAMP levels (Fig. 1) and decreased PexoT-lacZ expression (Figs. 3A and 3B) also showed reduced TM, including ΔfimL, ΔcyaB, ΔcyaAΔfimL, ΔcyaBΔfimL, and ΔcyaAΔcyaB mutants in both the PAO1 (Fig. 3C) and PA103 (Fig. 3D) backgrounds.

In addition, we generate specific IFNγ mutants that show decreased interaction capabilities towards LcrV, enabling us to map the interaction region to two basic C-terminal clusters of IFNγ.

Recently, Morello et al. [ 26] constructed rice mutants that had decreased splicing efficiency, but retained the loosely defined motifs identified by Rose et al. [ 16].

In mice, mutants that exhibit decreased mitochondrial respiration such as Surf1 −/− (mutation in cytochrome c oxidase) [ 8] and Mclk1 +/− (heterozygous knockout of the mouse homolog of clk-1) have long life spans [ 7].

Combination of the positive mutants resulted in the best mutant M31 that decreased its pH optimum for 1.5 units and showed increased catalytic activity at pH < 5.0 compared to the wild-type enzyme.

Recently, Lefebvre et al., 2011 showed an Arabidopsis mutant (esk1) that decreased in cold, salt tolerance and water use efficiency was severely defective in chemical composition of xylem cell wall, altered vascular tissues and impaired water transport.