Sentence examples for mutants that bind from inspiring English sources

The presence of class 1 HIF-2α mutants that bind pVHL like WT when synthetically hydroxylated but fail to be hydroxylated by PHD2 suggested to us that class 1 and class 2 mutations may differentially affect PHD2 binding.

We will use ribosome display to select Cyt1Aa mutants that bind other Cry toxins as a way to develop tools for improving Bt Cry toxicity against specific insect targets.

More recent studies described 2 C3 mutants that bind CFB with higher affinity, resulting in a more stable C3 convertase complex.

Expression of activated Ras effector domain mutants that bind Raf, PI3K, or RalGEF are sufficient to induce the anchorage-independent growth of the human mammary epithelial cell line HME16C and are associated with up-regulation of EGFR ligands.

A breakthrough approach to identifying PARP-1 targets proteome-wide has been recently reported by Carter-O'Connell et al. using PARP-1 and PARP-2 mutants that bind a "clickable" NAD+ analog, followed by copper-catalyzed conjugation to an azidoalkyl reporter ("click" chemistry) and tandem mass spectrometry.

Noticeably, in both the MG-132 and concanamycin A experiments, co-expression of Oxr1-C with Fus and Tdp-43 mutants that bind poorly to Oxr1-C (Fus P517L, Tdp-43 and1G and Tdp-43 D169G; Fig.  2B) does not show a reduction in Fus or Tdp-43 cytoplasmic inclusions, suggesting that the binding of Oxr1 to Fus and Tdp-43 is necessary to influence inclusion formation.

Only the mutants that bound to YopJ, P15 and P16, were acetylated by YopJ (Figure 6B).

Nine rounds of FACS were used to isolate mutants that bound with high affinity to αvβ3 integrin (Table S2).

Those mutants that bound AZD9773 were analysed for their ability to induce cytotoxicity in L929 cells (Supplementary Table S1, available at http://www.bioscirep.org/bsr/033/bsr033e060add.htm) and their susceptibility to inhibition by AZD9773.

Additionally, the ribbon organization of the Golgi is disturbed in KIF1C siRNA cells, a phenotype that can be suppressed by KIF1C expression, and not by the loop 6/10 mutant, but, significantly, can be rescued by a KIF1C mutant that binds Rab6 but not microtubules.

Cortical retention of Lgl disrupts planar spindle orientation, but only when Lgl mutants that can bind Dlg are expressed.