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The similarities of tracheal and salivary gland phenotypes in γCOP mutants suggest a common cellular mechanism expanding tubular organs.
In addition, abnormal circadian periods in clock mutants suggest a common molecular machinery responsible for circadian rhythmicity.
Reviewer 3: The subtle phenotypes associated with MUL1 mutants suggest a compensatory role of this pathway.
Taken together, the observed alterations of codon occupancy in Dnmt2 mutants suggest a reduced translation fidelity due to the lack of C38 methylation on tRNA-Asp.
Synergistic effects of mutations with gradually more severe growth retardation phenotypes in double and triple mutants suggest a similar function of the three genes.
I believe the manuscript suitable for eLife if the authors address these concerns: 1) The subtle phenotypes associated with MUL1 mutants suggest a compensatory role of this pathway.
Similar(50)
In contrast, the inhibitory effects of TGFbRII and ACTRIIA mutations were only observed in the cells stably expressing the receptor mutants, suggesting a possibly involvement of other unidentified mechanisms that require further investigation.
SRO7 was initially isolated as a high-copy suppressor of rho3 mutants, suggesting a role for Sro7p in maintenance of actin polarity [20], [21].
In contrast to wild-type fish, a comparison of 1- and 2-year old ACHE mutants suggests a delay in the onset of cognitive aging.
Interestingly, the overall staining intensity was much lower in homozygous Dicer mutants, suggesting a possible downregulation of L1 in retinal axons.
The variety of Tud structures seen in the different mutants suggests a complex and dynamic mechanism in nuage assembly involving multiple interactions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com