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Exact(5)
In addition, the proposed debugging technique can avoid the computation of unnecessary mutants so that the results show 2.9× average reduction of the number of mutants to be processed.
As in all genetic screens, primary screens represent a rough first pass through a large number of mutants so that the bulk of the analysis (secondary screens) can be focused on the most promising candidates.
Maternal Smn was removed from smn mutants so that early defects in motor neurons could be examined.
The modeler might therefore wish to set a different total time period in the simulation settings for these slow mutants, so that the overall number of cycles is comparable to the fast mutants, without slowing down the entire process by increasing the simulation time for all of the mutants.
Therefore, three mutations, N70G, S95R, and H222R, which were predicted to stabilize the interface significantly and are distant from each other, were combined into one triple and three double mutants so that all seven possible mutual combinations of the three mutations were studied.
Similar(55)
This is consistent with the idea that the Aux/IAA-ARF network is differently configured but not globally down-regulated in the mutant, so that some phenotypes are suggestive of auxin resistance, but others are not.
A similar pattern of CO protein accumulation was observed in spa1 7 and cop1 4 mutants between 14 h after dawn and the following morning, but the rise in the abundance of the protein was delayed in the spa1 7 mutant, so that it could not be detected until 14 h after dawn.
Given that there was no significant loss of a class of more severely affected animals, we suggest that the apparent difference reflects a delay in tissue replacement in the mutant, so that most animals end up with milder defects by the end of pupariation than were apparent during the time window for making the movies.
Given that there was no evidence for loss of a class of more severely affected animals, we suggest that the apparent difference reflects a delay in tissue replacement in the mutant, so that most animals end up with milder defects by the end of pupariation than were apparent during the early pupal time-window in the videos.
Again, epistasis in this case may be due to high sensitivity of the ruvABC and uvrD mutants to UV, so that Lula remains mostly repressed when these mutants are already mostly dead (see above).
This PCR bias affects the accuracy of mutant allele burden, so that long ITD mutant is measured to lower level than expected.
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