In addition, nbr mutants showed dramatic loss of climbing ability: while wild-type animals show little change in climbing ability even at 30d (>90% of wild-type flies successfully climbed at 30d), nbr null animals showed a dramatic decline already by 20d (∼50% of flies failed to climb) (Fig. 4C).
The rescued viral mutant showed dramatic reductions in levels of both viral RNA and viral protein in host cells.
In addition, three mutants, envZ, ompR, and envZ/ompR double-mutant, showed dramatic reduction in swarm size, but with increased density.
In A. fumigatus, the calcium/calmodulin-dependent kinases and calcineurin catalytic subunit cnaA mutant showed dramatic hyphal defects, including decreased apical extension and polarized growth (Steinbach et al. 2006).
The MATa and MATα ssn8 mutants both show dramatic same-sex mating, whereas overexpression of SSN8 blocks this process (Fig. 3A).
Another complication is that DLG mutant larvae show dramatic underdevelopment of the subsynaptic reticulum (SSR), a dense infolding of postsynaptic membrane that appears during larval NMJ growth [ 16, 17, 19, 24].
Utilizing constructs of wild-type and mutant PXN, we show dramatic effects of the mutations of PXN on actin cytoskeletal function, as well as alteration of mitochondrial localization and dynamics.
Consistent with this notion is that the Ca3 and Ca4 mutants show more dramatic effects on kcat/ KM and K0.5.
To determine the effectiveness of our primary screen, we tested the only mouse mutant strain (αCaMKII+/−) known to show dramatic deficits in remote, but not in short-term, memory.
AtTRM10 and AtTRM82 mutants which showed dramatic decrease of mG and mG modified nucleosides respectively, did not show any phenotype under LD conditions.
