Exact(2)
SCM3 is involved in the localization of CSE4, and SCM3 deletion mutants show disrupted localization of the centromere [23].
The Gsk3 Neurod6 mutants show disrupted cytoarchitecture.
Similar(56)
Open image in new window Figure 4 Human ASPM mutant organoids show disrupted cerebral development.
A number of zebrafish mutant lines show disrupted otolith formation; of these, einstein, menhir (Whitfield et al., 1996) and monolith (Riley and Grunwald, 1996; Riley et al., 1997), like atoh1b morphants, form only one otolith during early development, and so are good candidates for ear-specific components of otolith tethering.
The first biological clock genes, for example, were identified by examining Drosophila mutants that showed disrupted daily activity cycles.
One mutant (I573A) showed disrupted glycosylation and reduced trafficking kinetics.
Dicer-2 mutant flies also showed disrupted organization of nucleoli and decreased stability of rDNA repeats.
Differentiation of germline cells into oocytes coincides with asymmetric localization of proteins and mRNAs that set up the anterior-posterior (A-P) and dorsal-ventral (D-V) axes within the oocyte [ 18]. lkb1 mutant germline clones showed disrupted localization of various mRNAs resulting in defective oocyte polarity [ 19].
An AtSPL8-knockout mutant obtained by transposon tagging showed disrupted trichome formation (Unte et al. 2003).
Genetic bam -mutants and bam -RNAi flies showed disrupted cyst formation during oogenesis, resulting in ovaries containing an excess number of cells that cannot differentiate into gametes (McKearin and Spradling 1990; Chen and McKearin 2003; Ni et al. 2011).
Thus, talpid 3 HCs showed disrupted polarity.
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