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These mutants should prove useful in the further design of anticancer diagnostics/therapeutics.
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We selected the cpaAIR gene for gene disruption since the predicted 176a insertion site generated a high predicted insertional score (7.3), gene disruption is unlikely lethal, and the resulting mutant should prove useful for future genetic and metabolic engineering applications by abolishing the requirement for methylation of plasmid DNA prior to electrotransformation [ 22, 35].
The Ctgf Lo-Hi mutant mice should prove useful in further understanding the function of CTGF in fibrotic diseases.
Such a feedback was used in Figure 6 to suggest new submodels for finger II mutants, and, in all likelihood, should prove useful elucidating other context-dependent effects from adjacent ZFs or DNA, which are quite subtle to generalize.
As all of these mutants were constructed in the same manner, in the same genetic background, this collection should prove useful for the construction of multiple gene deletions for the study of genetic redundancy, and for the rational development of vaccine candidates.
That should prove beneficial.
This should prove interesting.
But such spats should prove surmountable.
That should prove intensely traumatic.
The chemistry should prove fascinating.
Peng, ranked 30th, should prove a more formidable foe.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com