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These data are consistent with the ATPalpha CJ mutants representing a range of loss-of-function phenotypes from mild hypomorph to strong loss-of-function.
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Some of these mutant genes encode components of signaling pathways such as the fibroblast growth factor and Wnt pathways that play evolutionarily conserved roles in other branched organs, These mutants represent a still largely untapped resource as most of them have not been studied in detail in relation to placental morphogenesis.
Therefore, these mutants represent a valuable recourse to study the mechanisms underlying the non-specific phenotype.
The core set of 117 genes up-regulated across all four canonical miRNA biogenesis mutants represented a conservative starting point to identify novel miRNAs and targets.
These homozygous lethal mutants represent a potential treasure trove for the biomedical community.
Hence, these mutants represent a novel approach of targeting non-traditional virulence determinants to generate a highly attenuated bacterial strain.
Genes required for intestinal gcs-1p::gfp expression in prdx-2 mutants represent a broad range of functional groups.
The possibility that none of the extant inx-21 mutants represented a true null allele was therefore explored.
Thus, the studies using the deletion mutants represent a somewhat artificial condition although it is suggestive of potential mechanisms.
These mutants represent a useful research tool in furthering the understanding of NPA-binding [ 36], cellulose biosynthesis and all its complexities.
In contrast, rpk1 mutants represent a loss-of-function state and form late SAMs at correct positions or eSMs ectopically on top of cotyledons.
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CEO of Professional Science Editing for Scientists @ prosciediting.com