Sentence examples for mutants relevant to from inspiring English sources

Protein protein interaction analysis revealed that Trp mutants relevant to amino acid positions 103 and 149 lost the ability to bind BlDnaK.

They created a null allele of the rab7 gene in Drosophila, as well as inducible transgenes expressing the following variants: wild-type, constitutively active, dominant-negative and four mutants relevant to CMT2B, along with wild-type and one mutant for human rab7A.

Having determined both the agonist and antagonist responses in the assay with wild type AR, we next wanted to examine the assay performance with an AR mutant relevant to prostate cancer.

Which, if any, of the various phenotypes of insulin pathway mutants are relevant to longevity?

It appears premature, therefore, to conclude that loss-of function phenotypes like reduced NOTCH signaling that were reported in overexpression studies with FAD PSEN mutants are relevant to the clinical phenotype of FAD patients, or may even contribute to the pathology of sporadic AD.

The Drosophila NMJ is a glutamatergic synapse that resembles excitatory synapses in the mammalian spinal cord, so the reduction of organized presynaptic microtubules that we observe in spastin mutants may be relevant to an understanding of human Spastin's role in maintenance of axon terminals in the spinal cord.

As the structures of the mutants are more relevant to the reaction mechanism, they are discussed in more detail in that section.

The shift of betweenness and closeness values of binding site residues in the mutant polymerase is relevant to the mechanism of drug resistance of VX-222 and ANA598.

For production of AVR-Pik alleles and mutants, relevant pOPIN constructs were introduced into SHuffle cells.

The mutants tested were those relevant to our evolutionary model, including a deletion of N-terminal insertion (αHext−/βA mutant, where amino acids 6 27 have been deleted), a deletion of the proline-rich wrist region insertion (αHPWR−/βA mutant, where amino acids 68 85 have been deleted) or in tandem deletion (αHext-PWR−/βA mutant) (Fig. S4, Table S3).

It is this latter finding that may be relevant to mutant p53 targeted drug development because in mutant p53 cancer cells, the levels of the mutant protein are high.