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The rates of deamino-NADH oxidase activity among the nineteen mutants ranged from 32 to 94% of the wild type rate.
Pearson correlation coefficients obtained for predictions within each of the 12 individual mutants ranged from 0.74 to 0.96.
The percentage of Pin animals in double mutants ranged from 97 100%, consistent with the enhancement observed for fbn-1 RNAi) fbn-1 RNAipersensinive backgrounds.
The IC50 for these resistant mutants ranged from 2- to 8-fold above the IC50 determined for unmutagenized MDR-sup S. pombe.
The concentration of hTP was ∼8.8 mg/ml and that of the various hTP mutants ranged from 7.5 to 20 mg/ml.
Of 8525 probesets, the total number of genes differentially expressed with respect to these dwarf mutants ranged from 151 (contrast snell25) to as many as 987 (contrast ames3b) (see Table 2).
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These Met mutants range from high to low in tyrosine kinase activity [20], [21], [22] and develop a unique tumor spectrum of primarily sarcomas and lymphomas on a C57BL/6;129/SV (backgroundound [19].
It was shown in vitro that the frequencies of emergence of fluoroquinolone-resistant mutants range from approximately 10−6 to 10−8/cell/generation [ 122].
The phenotypes of these mutants range from temperature-sensitive (ts) sterile (presumed hypomorphic allele) to L1 arrest (presumed null allele; i.e., phenocopies ama-1 deletion alleles).
In addition, we observed considerable heterogeneity in the rest and activity phenotype in Bdr mutants ranging from robust and entrained rhythms to highly irregular circadian profiles.
The number of mutations identified in each mutant ranged from 33 to 77 (Table 2), which closely matches the number of mutations (30−64) predicted using Canavanine-resistance mutation rates in Gruber et al. (2012).
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