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While ciliary ultrastructure is normal in most mutants, one of the mutant loci is essential for the formation of proper microtubule architecture in the axoneme of pronephric cilia.
We have carried out a structural analysis of six NF-κB p50 dimer interface mutants; one of them revealed a remarkable alteration.
About equivalent mutants: one of the objectives of the study is to verify if a given mutation produced is detected by FindBugs Tool, and this is done statically, without the necessity of the mutant execution.
Here we provide evidence that catalytically inactive LOXL2 mutants, one of them unable to be secreted, induce and sustain a full EMT process, indicating that intracellular LOXL2 drives EMT independent of its enzymatic activity.
Our results are complementary to these recent findings and recapitulate hyper-recombination with specific BRCT mutants (one of them naturally occurring) unable to bind critical proteins, and link genomic instability with ubiquitination-dependent processing that occurs late in HRR.
When binding becomes more exothermic, as in the case of the Trp203 mutants, one of three situations is most likely involved: (1) the bound complex experiencing a net increase in the strength of noncovalent interactions, (2) the unliganded protein being less hydrated, or (3) a combination of both.
Similar(53)
The R138Q NPHS2 mutant (one of the most common found mutation) results in retainment of the mutant podocin in the endoplasmatic reticulum.
For the total sulphur and sulphate ion content data of old3-1old3-1odd-lerodd-ler old3-1old3-1odd-lerodd-ler old3-1old3-1odd-lerodd-ler old3-1old3-1odd-lerodd-ler old3-1old3-1odd-lerodd-lera points four replicates of 17 plants were used.
The course has a modular scalability in that five different p53 mutants were studied each term, and each lab section (10 students) studied the same five p53 mutants (one pair of students per mutant p53 allele).
Hartlieb identified three sets of mutants, one has no effect and the third reduces nucleocapsid interaction.
Owens and co-workers from Celltech (now part of Union Chimique Belge, UCB) prepared serine- or threonine-to-cysteine mutants at one of five sites on the CH1 domain of an antibody against the tumor-associated glycoprotein TAG72.
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