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We found that constitutive expression of TGMV- TrAP in Arabidopsis thaliana caused morphological abnormalities that mimic loss-of-function mutants of numerous TGS components including lhp1 (like-heterochromatin1) and clf.
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Although the period of the metabolic cycles of numerous mutants is shorter than wild type [20], an expansion of the metabolic cycle we observed in cells with more mtDNA is very rare [22].
They indicate that NMD deeply influences the expression of numerous mutants with an expected crucial role in MSI-driven tumorigenesis and negatively impacts the host immunity against MSI cancer cells.
Thirdly, the powerful genetic approaches and the availability of numerous mutant alleles make it possible to dissect the mechanisms underlying the function of the compounds.
The first monitored the calpain cleavage of numerous mutant proteins containing internal deletions within the CCR (Fig. 2).
The cells of mutant strain B consisted of numerous very elongated forms and a few other distorted shapes.
The availability of numerous mutant strains has led to the identification of many unexpected genetic pathways that can influence the folding and toxicity of misfolded substrates (Hsu et al., 2003; Morley and Morimoto, 2004; Garcia et al., 2007).
A typical example is in prion disease such as GSS syndrome whose pathological hallmark is the presence of numerous mutant prion protein amyloid deposits throughout the cerebral cortices, especially in the cerebellum [ 12], where [F]FDDNP binding has been found to be elevated [ 3].
TBASE contains an exhaustive list of knockout-related citations and provides an extensive phenotypic characterization of numerous behavioral mutants that is extracted directly from the literature.
Previously, we conducted forward genetic screens for mouse infertility mutants, resulting in the isolation of numerous infertile strains with varying phenotypes (Ward et al. 2003; Handel et al. 2006).
The team produced numerous mutants of tobacco plants that they thought were capable of growing independently of the presence of these two hormones.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com