Sentence examples for mutants observed in from inspiring English sources

The dominant nature of the toxic gain-of-function of FUS mutants observed in our study is consistent with recent FUS KO and mutant transgenic mice studies.

However, the increase in transcription of acid resistance genes in the hupA and hupB single mutants observed in cluster 2 was insufficient to permit low pH adaptation (Fig. 4).

Although some of the more virulent color mutants showed increased resistance to hydrogen peroxide, overall phenotypic characterizations including secondary metabolite production, metalloproteinase activity, and germination rate did not reveal a general mechanism accountable for the enhanced virulence of these color mutants observed in the insect model.

As Pfmdr-1 is a major modulator of resistance to these drugs [10], monitoring in the future in which measure the high proportion of Pfmdr-1 mutants observed in Madagascar can have an impact on the resistance of these antimalarials, even if at the moment this impact seems modest [11].

Thus, the behavioural phenotype of crh-1 tz2) crh-1 tz2bserved in quantitative and qualitative assays suggest that CRH-1 function is imutantst fobserved

This rotational variability may explain the apparent ∼15° rotation of the AAA-2 wild-type ring relative to the mutants observed in the symmetrised reconstructions.

For example, the ALK mutant F1174L observed in SH-SY5Y and KELLY neuroblastoma cell lines is sensitive to TAE684, whereas the R1275W ALK mutant observed in the SMS-KCNR cell line is unaffected.

These experiments suggest that the attenuated phenotype of the mptC mutant observed in vivo is not due to defective entry or initial persistence in macrophages.

Testing these 26 candidates identified seven orthologous negative interactions, with a genotoxin-aggravating effect on the double mutant observed in most cases.

Indeed, the same aberrations in cortical cytoarchitecture, hippocampal disturbances and spontaneous epilepsy that have been detected in RGC-targeted Tsc2 mutants were observed in RGC-targeted Tsc1 mutant mice.

The metabolic changes characteristic of the chaperone deficient mutants, not observed in neither CCCP treatment, nor in the COA3-null mutant, may have a role to mitigate the proteotoxicity by aiding cellular adaptation to requirements of coping with stress.