directly interact with Xyr1, intracellular accumulation of the inducer caused by the bgl2 mutation might represent an artificially evolved ability for a T. reesei mutant in which cellulase production via Xyr1 is elevated.
If BRCA1 and BRCA2 are DNA repair genes, then the p53/p21-mediated p53/p21-mediateden in BRCA mutant tissue migrowthpresent arrestckpoint' reseense to spontaneous DNA damage arining as a result of the failure of DNA repair processes.
Histopathology could reveal early and subtle lesions before they are severe enough to cause detectable phenotypes, and, for some mutant lines, might represent the only detected abnormality (Schofield et al., 2012).
sdn-1 (zh20 ); mab-5 (e1751 ) showed much anterior AQR and PQR migration, suggesting that sdn-1 is required for posterior migration in the mab-5 (e1751 ) gain-of-function mutant, which might represent sensitized backgrounds that reveal the effect of SDN-1 on posterior migration.
Based on these data and the severity of the clinical phenotype of the patient, we expect that this mutant has even less residual activity than the LIG4 mutants described before and might represent a null mutation.
Since 3H4MV biosynthesis pathway has not yet been identified, these mutants might be useful in the study of this pathway.
The "X-Men" mutants might be headed to your small screen, and not in cartoon form this time.
However, C75U mutants might not represent properly folded ribozyme active sites, as the keto group on uracil does not hydrogen bond with other active site members in the same way as cytosine's exocyclic amine.
In a more general scenario, the FPV cleavage mutants might also represent a powerful alternative to strain A/PR/8/34 that is currently used almost exclusively as donor of the internal viral genes for the generation of reassortant seed strains on which human influenza vaccines are based.
Thus, the putative mutants from this screen might represent mutations in uncharacterized genes, new mutations in the maize RNA-directed transcriptional gene silencing pathway, or mutations in genes encoding proteins previously implicated in other gene silencing pathways.
