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Indeed, the increased affinity for peptide analogues and the decreased affinity for inverse agonists previously reported for D74 mutants may reflect that the mutant shows constitutive association with β-arrestin2, which has been reported to form a high affinity ternary complex, similar to the G protein bound receptor state [44], [45].
The lower frequency of selection of other mutants may reflect a decreased ability of other eEF-2 variants to support protein synthesis, thereby causing a greater growth defect, and decreasing the chance that a colony will grow big enough to be detected and picked.
This decrease in gene expression in aplnrb mutants may reflect a failure of cells to reach the APLM during development.
One possible explanation is that the reduction of lymphatic sprouting in Nrp2 mutants may reflect the lack of VEGFC/VEGFR3/NRP2-mediated positive signaling.
The As and Cd-sensitivity of the latter mutants may reflect different functions/targets of the corresponding proteins under the two stress conditions.
The increased ferulate levels in these bmr mutants may reflect cell wall compositional and/or architectural changes that may influence the rate of glucose release during enzymatic saccharification from bmr30 and bmr31 stover.
Similar(51)
The correlation of amino-acid biosynthesis and phosphate utilization groups with growth rate in the compendium of deletion mutant may reflect limitation of the media used.
If as mentioned previously SMF-2 is protective against Mn toxicity, the resistant phenotype of the smf-1 eh5) smf-1 eh5y reflect the overexpression of Smutant
Faster autophagy in the buffy mutant may reflect a positive signaling role for S6K in autophagy initiation that contributes to this phenotype.
The kinetic and binding results with the lysine mutant may reflect a steric clash with the cofactor, despite our observation in crystals that it could be oriented toward the metal center.
The spread of Pfmdr-1 mutant alleles may reflect a better fitness of parasites harbouring them or a better efficacy of the transmission [35].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com