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PrP mutants may escape quality control cellular pathway and accumulate inside the cell [19], [20], [21], [22].
Alternatively, mutants may escape extinction by intragenomic rRNA homogenization, which reverts the mutation and thus restores ITS2 functions and fitness [ 74].
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Reports in colorectal cancer suggest BRAF-mutant tumors may escape inhibition by amplifying receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR), and EGFR amplification and fusion are common alterations found in adult glioblastoma multiforme lesions [ 7, 12].
| JPMorgan executive may escape penalty.
Hence, Ox40 expression in MS lesions may escape detection.
Proliferating bacteria may escape granulomatous isolation, spreading to other organs.
By allowing unfavorable transitions, the MCMC may escape local minima.
Your bug may escape indoors.
These 'vaccine escape' mutants may pose a serious threat to the success of the global HBV vaccine campaign.
Considering the above, it could be proposed that DNA viruses with accurate proof reading such as cytomegalovirus (during acute virus infection) would be at a disadvantage in a high ISG environment, as the development of escape mutants may take too long.
Therefore, the authors postulated that such "serially passed" immune-escape mutants may facilitate improvements in the therapeutic efficacy of phage.
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