Sentence examples for mutants located in from inspiring English sources

At the same time, the integrity of F595 was also key to several other JAK2 mutants located in different locations of the protein, JAK2 K539L, JAK2 T875N and JAK2 R683G.

Experiments with alanine mutants, located in the complex interfaces, yielded an energy map for the contact areas of the Ras/effector complexes, which could be differentiated into enthalpy and entropy contributions.

Figure 3A shows that some mutants located in helix α-4 completely blocked toxin action even at sub-stoichiometric ratios.

The analysis of additional point mutants located in and around the cap-binding pocket has allowed us to address this question in more depth.

To examine the hypothesis we selected a representative set of mutants located in different functional domains of the CBS molecule.

In this study, we examined systematically catalytic and folding-related structural properties of a panel of 27 mutants located in different functional domains of the CBS molecule.

Interestingly, whereas the MT1-G166E MT1-I212T212T mutappearppear to be biased towards the ERK1/2 pathway, the MT2-V124I mutant (mutation located in TM3) appears to be biased towards the cAMP pathway, as this mutant fully activates the cAMP pathway, but only partially the ERK1/2 pathway.

Plasmid rescue showed that the p-element of this mutant located in the first intron of the gene silver (svr) (Fig. 1A).

Finally, the G439D mutant, located in domain II loop 3, also showed an oligomeric structure that was mainly found inserted into the membrane.

The I35T mutant, located in β3 strand, showed a fast increase in ThT fluorescence (figure 2), and therefore in the rate of oligomerization, as also evidenced by the gel chromatographic analysis (data not shown), while the other mutant here investigated, L67V, ologomerizes with a slower rate, similarly to WT SOD1.

However, when we used the previously described non-toxic Cry11Aa-E97A mutant, located in helix α-3 that is affected in oligomerization [26], we found that this mutant did not show a DN phenotype since it was unable to inhibit the toxicity of the wildtype toxin when tested at 0.5∶1 or 1∶1 ratios.