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Under normal culture conditions (20°C), hif-1 (ia04) mutants lived approximately 20% longer than wild-type animals (24 days, compared to 20 days for wild-type N2) (Table 1).
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Zygotic Dicer null mutants live approximately 14 days, because there is sufficient maternal Dicer mRNA deposited into the oocyte [ 19].
In contrast to hsd-1 and other eak single mutants, eak-7 single mutants live approximately 25% longer than wild-type animals, and this lifespan extension requires DAF-16/FoxO as well as the DAF-16/FoxO cofactors HSF-1 and SMK-1 [ 33].
At 25°, daf-12 (null) mutants live approximately as long as wild-type animals do, indicating that the effect of daf-12 (null) on the life span of animals subjected to daf-2 RNAi is unlikely to be due to general frailty.
Neanderthals lived approximately 250,000 years ago in present-day Eurasia.
Tiktaalik lived approximately 375 million years ago.
Denisovans and Neanderthals were hominins that last lived approximately 30,000 years ago.
Ames dwarfs live approximately 50% longer than non-mutant siblings and are protected from age-related metabolic perturbations and cancer [ 10, 13].
On average, women live approximately 2 years longer than men.
Interestingly, however, these mutants live significantly longer 40-600%) and healthier lives compared to their normal siblings.
(C ) The unc-43(n498);cnb-1(ok276) cnb-1 ok276 cnb-1 ok276ger than either single mutant.
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